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Differential Gene Expression during Multistage Carcinogenesis

By Bowden, G. Tim

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Book Id: WPLBN0000225732
Format Type: PDF eBook
File Size: 0.5 MB
Reproduction Date: 2005

Title: Differential Gene Expression during Multistage Carcinogenesis  
Author: Bowden, G. Tim
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Bowden, G. T. (n.d.). Differential Gene Expression during Multistage Carcinogenesis. Retrieved from

Government Reference Publication

Introduction: During the process of either chemical or radiation carcinogenesis, the progression of target cells through a premalignant to malignant state is accompanied by a variety of morphological, cytological, and biochemical alterations. Presumably, these phenotypic changes result from either qualitative alterations in encoded gene products or changes in the levels of expression of cellular genes. One class of cellular genes that is known to be altered during carcinogenesis and is thought to play a functional role in tumor formation is the cellular proto-oncogenes (1-3). In addition to the proto-oncogenes, there is a class of cellular tumor-suppressor genes whose inactivation may be required for expression of the tumorigenic (i). Both chemical carcinogens and ionizing radiation are known to induce the types of mutations that have been observed to activate proto-oncogenes to transforming oncogenes and to inactivate tumor-suppressor genes. These mutations can lead to structural changes in encoded gene products or loss of normal control of expression of these genes.


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