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World Health Organization : Development of Health Services, Smallpox Eradication, Smallpox, Working Paper, No. 27: A Comparative Study of Clinical Reaction Observed After Application of Several Smallpox Vaccines in Primary Vaccination of Young Adults

By M. F. Polak, Dr.

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Book Id: WPLBN0000054476
Format Type: PDF eBook
File Size: 1.0 MB
Reproduction Date: 2005
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Title: World Health Organization : Development of Health Services, Smallpox Eradication, Smallpox, Working Paper, No. 27: A Comparative Study of Clinical Reaction Observed After Application of Several Smallpox Vaccines in Primary Vaccination of Young Adults  
Author: M. F. Polak, Dr.
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
Publication Date:
Publisher: World Health Organization

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Polak, Dr, M. F. (n.d.). World Health Organization : Development of Health Services, Smallpox Eradication, Smallpox, Working Paper, No. 27. Retrieved from http://worldpubliclibrary.org/


Description
Medical Reference Publication

Excerpt
Four smallpox vaccines from different production laboratories were compared in primary vaccination of young adults. Morbidity rate, high fever rate and prolonged fever rate, as defined in this report, were used as gauges for pathogenic potency. Special batches were prepared, in addition, from two of these vaccines after three passages on calf skin Two vaccines, prepared from the Elstree strain-a sheep lymph and its third calf-passagewere found to be of low pathogenicity. Two calf lymphs, prepared from the Copenhagen strain and the Bern strain respectively, caused clearly higher rates of illness and of height and duration of fever. Two calf lymphs from the Ecuador strain took up an intermediate position. Vaccine potency, as assessed on the chorio-allantoic membrane of developing chick embryos, seems to be of no significance for the course of vaccinia disease caused by two pustules. Besides the pathogenicity of the vaccinia strain, ill-defined extraneous factors might be of importance for the degree of illness observed affer primary smallpox vaccination.

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