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Asbestos Affects the in Vitro Uptake and Detoxification of Aromatic Compounds

By Brown, Rebecca C.

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Book Id: WPLBN0000229400
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Asbestos Affects the in Vitro Uptake and Detoxification of Aromatic Compounds  
Author: Brown, Rebecca C.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collection: Government Library Collection
Subcollection: Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

Government Reference Publication

Excerpt: It is our opinion that despite extensive experimentation there has been no unequivocal demonstration of the short-term genotoxicity of fibrous dusts; thus the carcinogenic activities of these materials remain largely unexplained. There are several possible explanations for this, but perhaps the most likely are: (1) fibrous dusts could be so weakly carcinogenic that they only exert their in vivo effects by virtue of their long residence times in damaged tissue or (2) they act by enhancing the activities of other agents even when apparently acting alone. In this paper we address ourselves primarily to this second possibility. There are several possible mechanisms whereby fibrous dusts could act as carcinogenic enhancers, although the one which has received the most attention is that fibers could act as carriers mediating the transfer of carcinogens into tissue by holding them in situ for longer periods than would he the case for the carcinogen alone. Lakowicz and his c e workers U, 2) have demonstrated that fibers can catalyze the transfer of hydrocarbons into solution in lipid membranes. The joint effects of fibers and chemical carcinogens have recently been reviewed 19). We have been investigating the effect of various.


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