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Differentiation of Mammary Stem Cells in Vivo and in Vitro

By Barraclough, Roger

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Book Id: WPLBN0000213514
Format Type: PDF eBook
File Size: 0.8 MB
Reproduction Date: 2005

Title: Differentiation of Mammary Stem Cells in Vivo and in Vitro  
Author: Barraclough, Roger
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collection: Government Library Collection
Subcollection: Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

Government Reference Publication

Excerpt: The mammary gland of the adult female rat consists of a system of branching duds terminating in alveoli and embedded in a fatty stroma (1). The mammary ducts are composed of one or more layers of cuboidal, epithelial cells, some of which border a lumen that is continuous throughout the ductal system. The epithelial cells are surrounded by a layer of elongated, myoepithelial cells (2,3). These two fully differentiated cell types have been distinguished in the past by their characteristic ultrastructural morphologies. The ductal epithelial cells possess apical microvilli and specialized junctional complexes and associated desmosomes, whereas the myoepithelial cells possess smooth musclelike myofilaments with pinocytotic vesicles and basement membrane on their basal surfaces A thud functionally differentiated cell type, the secretory cell, is found in the mammary alveoli. This cell type is characterized by its ultrastructure and, during lactation, by the synthesis and secretion of milk products (45).


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